🧪 Detox & liver support
4 mechanistic pathways · 58 options
'Detox' is mostly marketing, and the underlying biochemistry is real and specific. The liver runs a two-phase system: Phase I makes compounds reactive, Phase II conjugates them to be safely excreted. Upregulating Phase I without Phase II capacity produces MORE reactive intermediates than you started with — which is why the sequence matters and why a lot of 'detox' products are the wrong idea executed confidently. And the elimination step is the one everyone skips: if bile and bowel aren't moving, conjugated toxins get deconjugated in the gut and reabsorbed.
The pathways
Phase II conjugation — the step that actually clears things
Glucuronidation, sulfation, glutathione conjugation, acetylation and methylation. This is where things become water-soluble and excretable. It is also the rate-limiting step for most people, which makes it the right place to start rather than finish.
Hepatocyte protection & liver function
Every one of these reactions happens inside liver cells, so protecting them is upstream of the whole system. Also worth stating plainly: the two most effective liver interventions available are drinking less and losing visceral fat.
Binders & interrupting reabsorption
Conjugated toxins go out in bile, into the gut — and gut bacterial beta-glucuronidase can cut the conjugate off and let them straight back in. That enterohepatic loop is why elimination is a real step rather than an afterthought, and binders exist to break it.
Alcohol, acetaldehyde & recovery
Alcohol is metabolised to acetaldehyde — considerably more toxic than ethanol — then to acetate. When acetaldehyde clearance lags, that is the hangover and the tissue damage. The interventions here target specific steps in that sequence.
Test before you choose a pathway
Every route below can be argued for on mechanism. Only bloodwork tells you which one is actually your problem — and picking the wrong pathway is the most common reason someone concludes "none of this works". Across all 4 pathways, these are the 17 markers worth having in front of you first.
Ordered together:
🥬 Full Micronutrient Screen🫀 Fatty Liver & Liver Health⚗️ Heavy Metals & Mineral BalanceYou have the pathways. Here is the stack.
The Detox & Liver Support Blueprint names the one compound I would start with in each of these 4 pathways, what it was chosen over, and why — plus 22 options to swap in or stack on top, every one of them priced and linked.
Open The Detox & Liver Support Blueprint →The protocols behind these
Dosing, stacking and cycle timing live inside the Academy, alongside the full interactive Vault and the Bloodwork Protocols.
Join the Academy — $10/mo →← Open Detox & liver support in the interactive Vault · All 21 goals
Frequently asked questions
This goal is broken into 4 distinct mechanistic pathways — Phase II conjugation — the step that actually clears things; Hepatocyte protection & liver function; Binders & interrupting reabsorption; Alcohol, acetaldehyde & recovery — across 58 compounds and supplements. Each pathway is a different argument about how the body gets there, so the useful question is which one matches where you are actually stuck.
The one that matches your actual limitation, which bloodwork usually settles faster than guessing. An appetite drug does nothing for someone who already undereats, and a thyroid intervention does nothing if your thyroid is fine. Each pathway page lists the markers that tell you whether it is your problem.
No. The 4 pathways are listed in mechanistic order, not by strength of evidence, and neither are the 58 options inside them. A lot of what works in this space has never had the trial run, and sorting by trial count would bury exactly the compounds you came looking for.