Inflammatory skin — acne, rosacea, eczema, psoriasis
One of 5 mechanistic pathways to ✨ Skin, hair & aesthetics · 14 options
These are immune and barrier conditions rather than ageing ones. The common threads are barrier failure, dysbiosis and an over-reactive local immune response — and the gut connection is real rather than fashionable.
Adult acne is usually one of two things — androgen excess or insulin resistance driving IGF-1 — and the two are treated differently. These markers tell you which you have.
hs-CRP (High-Sensitivity C-Reactive Protein)Fasting InsulinHbA1c (Hemoglobin A1c)Total TestosteroneDHEA-SVitamin D (25-Hydroxy)Zinc, RBC🧴 Adult Hormonal Acne covers these in one panel →
What engages this pathway
Ordered by how directly each one acts on the mechanism above — never by how much trial evidence exists. Each links to its full breakdown with dosing, half-life and vendor.
💉 KPV
The anti-inflammatory tripeptide from α-MSH, active in skin models without the pigmentation effect. Genuine interest in eczema and psoriasis; human trials are absent.
💉 Tretinoin
Normalises follicular keratinisation — the primary lesion in acne. Decades of evidence.
💉 Fluocinolone
A topical corticosteroid. Effective and, with chronic use, causes skin atrophy and telangiectasia — potency and duration both matter.
🧬 Zinc
Oral zinc has trial evidence in inflammatory acne, roughly comparable to some antibiotics with a better resistance profile.
🧬 Omega-3 (Fish Oil)
Reduces inflammatory acne lesions in trials; the EPA-derived resolvins are the plausible mechanism.
🧬 DIM
Where acne is hormonally driven, shifting estrogen metabolism can help — targeting the driver rather than the lesion.
🧬 Probiotic
Specific strains improve acne and eczema outcomes in trials; the gut-skin axis operates through immune tolerance and systemic inflammation.
🧬 Vitamin D
Immunomodulatory in skin, with trial evidence in psoriasis and atopic dermatitis.
🧬 Evening Primrose Oil
GLA for barrier lipid composition; best evidence in atopic dermatitis.
🧬 Sea Buckthorn
Omega-7 supports mucosal and skin barrier integrity.
🧬 NAC
Trial evidence in skin-picking and trichotillomania, and general antioxidant support for inflammatory skin.
🧬 Berberine
Where acne is insulin-driven — high-glycaemic diets raise IGF-1 and androgens, and that chain is well documented.
🧬 Gut Repair (EnteroMend)
Barrier repair upstream; intestinal permeability correlates with several inflammatory skin conditions.
🧬 Colostrum
IgG and growth factors for gut-barrier integrity.
The other 4 routes to skin, hair & aesthetics
Pick the pathway that matches where you are actually stuck. An appetite drug does nothing for someone who already undereats.
Want the protocols behind these?
Dosing schedules, stacking, cycle timing and Coach Cam's notes live inside the Academy — plus the full interactive Vault.
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Frequently asked questions
These are immune and barrier conditions rather than ageing ones. The common threads are barrier failure, dysbiosis and an over-reactive local immune response — and the gut connection is real rather than fashionable.
14 options are mapped to this pathway in the Vault, including KPV, Tretinoin, Fluocinolone, Zinc. They are grouped by the mechanism they act through rather than ranked by how much trial evidence exists — 11 carry clinical validation and 3 are mechanistic predictions.
Adult acne is usually one of two things — androgen excess or insulin resistance driving IGF-1 — and the two are treated differently. These markers tell you which you have. The markers worth checking are hs-CRP (High-Sensitivity C-Reactive Protein), Fasting Insulin, HbA1c (Hemoglobin A1c), Total Testosterone.
Unproven is not the same as ineffective. Of the 14 options on this pathway, 11 have clinical validation and 3 are graded theoretical — meaning the mechanism is sound but the specific human trial has not been run, which is true of a great deal of what works in this space. Nothing on this page is ordered by evidence tier, because sorting by trial count would bury the compounds you came looking for.