Hepatocyte protection & liver function
One of 4 mechanistic pathways to 🧪 Detox & liver support · 15 options
Every one of these reactions happens inside liver cells, so protecting them is upstream of the whole system. Also worth stating plainly: the two most effective liver interventions available are drinking less and losing visceral fat.
Before assuming toxins, rule out the two inherited causes of liver injury that are common and completely missable: haemochromatosis (iron) and Wilson's disease (copper). Both are one test each.
Comprehensive Metabolic Panel (CMP)Enhanced Liver Fibrosis (ELF) TestFerritinHereditary Hemochromatosis, DNACeruloplasminCopper, Serum🫀 Fatty Liver & Liver Health covers these in one panel →
What engages this pathway
Ordered by how directly each one acts on the mechanism above — never by how much trial evidence exists. Each links to its full breakdown with dosing, half-life and vendor.
🧬 Milk Thistle (Siliphos)
Silybin stabilises hepatocyte membranes and stimulates ribosomal RNA synthesis for regeneration. It is used intravenously as the antidote for death-cap mushroom poisoning, which is a serious demonstration of a real mechanism. Phytosome form for oral use.
🧬 TUDCA
A hydrophilic bile acid that displaces toxic hydrophobic bile acids and reduces ER stress. Genuine clinical use in cholestatic liver disease.
🧬 NAC
The paracetamol antidote. Restores glutathione faster than anything else available.
🧬 Liver Support
A blend spanning hepatocyte protection and conjugation support. Judge it on its components — no combination product here has been trialled as a unit, and the sequencing argument on this page matters more than any single blend.
🧬 Schisandra
Lowers ALT in human trials and induces Phase I and II enzymes in a balanced way — unusual, since most inducers push one phase.
🧬 Artichoke Leaf Extract
Choleretic and hepatoprotective, with liver-enzyme improvement in trials.
🧬 Dandelion Root
Traditional bile stimulant and mild diuretic.
🧬 Curcumin
Reduces hepatic inflammation and liver enzymes in NAFLD trials.
🧬 Alpha Lipoic Acid
Regenerates glutathione, vitamin C and vitamin E — an antioxidant that recycles other antioxidants.
🧬 Vitamin E
Biopsy-proven histological improvement in non-diabetic NASH in the PIVENS trial.
🧬 Choline Bitartrate
Required for VLDL export; deficiency causes fatty liver directly.
🧬 MediClear (Detox Shake)
A protein-plus-sulforaphane formulation providing amino-acid substrate for conjugation alongside Nrf2 activation — which is the correct combination, since Phase II conjugation consumes amino acids in quantity.
💉 Glutathione
Direct repletion where hepatic demand is high.
💉 Livagen
A liver bioregulator peptide from the Khavinson series.
💉 Svetinorm
Oral liver bioregulator, same series and same evidence caveat.
The other 3 routes to detox & liver support
Pick the pathway that matches where you are actually stuck. An appetite drug does nothing for someone who already undereats.
Want the protocols behind these?
Dosing schedules, stacking, cycle timing and Coach Cam's notes live inside the Academy — plus the full interactive Vault.
Join the Academy — $10/mo →← Open this pathway in the interactive Vault
Frequently asked questions
Every one of these reactions happens inside liver cells, so protecting them is upstream of the whole system. Also worth stating plainly: the two most effective liver interventions available are drinking less and losing visceral fat.
15 options are mapped to this pathway in the Vault, including Milk Thistle (Siliphos), TUDCA, NAC, Liver Support. They are grouped by the mechanism they act through rather than ranked by how much trial evidence exists — 9 carry clinical validation and 6 are mechanistic predictions.
Before assuming toxins, rule out the two inherited causes of liver injury that are common and completely missable: haemochromatosis (iron) and Wilson's disease (copper). Both are one test each. The markers worth checking are Comprehensive Metabolic Panel (CMP), Enhanced Liver Fibrosis (ELF) Test, Ferritin, Hereditary Hemochromatosis, DNA.
Unproven is not the same as ineffective. Of the 15 options on this pathway, 9 have clinical validation and 6 are graded theoretical — meaning the mechanism is sound but the specific human trial has not been run, which is true of a great deal of what works in this space. Nothing on this page is ordered by evidence tier, because sorting by trial count would bury the compounds you came looking for.