🫀 Heart, cholesterol & blood pressure
5 mechanistic pathways · 68 options
This is the goal with the strongest causal evidence base in the entire Vault, and the least excitement attached to it. ApoB particle count and blood pressure are the two variables with the most robust causal relationship to how long you live. Everything else here is refinement. Know your numbers first: ApoB, Lp(a) once in your life, blood pressure at home, and hs-CRP.
The pathways
ApoB & LDL particle reduction
Atherosclerosis is caused by ApoB-containing particles crossing into the arterial wall and being retained. Fewer particles, less retention — and the relationship is causal, dose-dependent and cumulative over a lifetime, which is why starting early matters more than starting aggressively.
Endothelial function & nitric oxide
The endothelium is a single cell layer regulating tone, clotting and inflammation. Its dysfunction precedes plaque by decades and is measurable long before anything shows on a scan — which makes it the earliest place to intervene.
Thrombosis, Lp(a) & residual risk
Plaque doesn't kill you — the clot on a ruptured plaque does. And Lp(a) is genetically determined, unaffected by diet and lifestyle, raised in about one in five people, and almost never tested. If you measure one unusual thing in your life, measure this once.
Cardiac energetics & heart failure support
The heart is the most mitochondria-dense tissue in the body — roughly a third of cardiomyocyte volume — and it never rests. Failing hearts are energy-starved, which is a substrate problem as much as a pump problem.
Venous & microcirculation
The forgotten half of the circulation. Veins return blood against gravity using valves and vessel-wall tone, and when that fails you get varicosities, heaviness, oedema and haemorrhoids. Different tissue, different mechanism, and genuinely responsive to flavonoids — this is one of the better-evidenced areas in botanical medicine and one of the least discussed.
Test before you choose a pathway
Every route below can be argued for on mechanism. Only bloodwork tells you which one is actually your problem — and picking the wrong pathway is the most common reason someone concludes "none of this works". Across all 5 pathways, these are the 21 markers worth having in front of you first.
Ordered together:
🫀 Real Cardiovascular Risk🩸 Clotting & Advanced Cardiac RiskYou have the pathways. Here is the stack.
The Cardiovascular Blueprint names the one compound I would start with in each of these 5 pathways, what it was chosen over, and why — plus 25 options to swap in or stack on top, every one of them priced and linked.
Open The Cardiovascular Blueprint →The protocols behind these
Dosing, stacking and cycle timing live inside the Academy, alongside the full interactive Vault and the Bloodwork Protocols.
Join the Academy — $10/mo →← Open Heart, cholesterol & blood pressure in the interactive Vault · All 21 goals
Frequently asked questions
This goal is broken into 5 distinct mechanistic pathways — ApoB & LDL particle reduction; Endothelial function & nitric oxide; Thrombosis, Lp(a) & residual risk; Cardiac energetics & heart failure support and others — across 68 compounds and supplements. Each pathway is a different argument about how the body gets there, so the useful question is which one matches where you are actually stuck.
The one that matches your actual limitation, which bloodwork usually settles faster than guessing. An appetite drug does nothing for someone who already undereats, and a thyroid intervention does nothing if your thyroid is fine. Each pathway page lists the markers that tell you whether it is your problem.
No. The 5 pathways are listed in mechanistic order, not by strength of evidence, and neither are the 68 options inside them. A lot of what works in this space has never had the trial run, and sorting by trial count would bury exactly the compounds you came looking for.