ADMA & SDMA
Naturally occurring inhibitors of nitric oxide synthase. ADMA blocks nitric oxide production, impairing blood vessel dilation; SDMA is primarily a kidney function marker.
A direct window into endothelial function — how well your blood vessels dilate. Relevant to blood pressure, erectile function and early cardiovascular disease, often before structural damage appears.
Optimal ranges, root causes, and the complete correction protocol — nutrition, supplements, lifestyle, hormones and peptides — plus 100+ other markers.
Unlock everything — $10/mo →📚 Böger RH, J Nutr 2004 — ADMA as a cardiovascular risk marker.
🩸 Test your ADMA & SDMA
Order directly through Marek Diagnostics — no doctor's visit needed, drawn at any Quest location in the US. Code CAMERON applies 10% off automatically.
Order this test — 10% off → Browse all 102 markers →What ADMA & SDMA is usually tested alongside
On its own, one marker is a data point. These panels include ADMA & SDMA plus the markers that make it interpretable — each names every test, why it is on the list, and loads the whole set into your cart in one click at 10% off.
includes this + 8 more markers — Family history of clots, stroke or early heart attack; on testosterone or oestrogen; long-haul travel; or a standard lipid panel that looked fine and you don't believe it.
Would you feel it? Symptoms ADMA & SDMA helps explain
People rarely search for a marker — they search for how they feel. These are the complaints where this marker is worth checking, and whether it is a first-line test or a follow-up once the obvious causes are ruled out.
Why your ADMA & SDMA might be wrong
Most abnormal results are interference, not disease. These are the things that measurably move this specific marker — check them before you change anything. Each one says whether the number is wrong and should be repeated, badly timed and should be redrawn, or real with a cause worth explaining.
Rises after eating, so a non-fasted draw measures your breakfast rather than your baseline.
Draw fasted, 10–12 hours, water only.
ADMA is cleared renally, so impaired kidney function raises it substantially without any additional endothelial problem.
Read against cystatin C eGFR.
What ADMA & SDMA means in combination
A single marker tells you a little. Combinations tell you the story — these are the named patterns this marker takes part in, and what each one points at.
Two mechanisms a standard lipid panel cannot see. ADMA inhibits nitric oxide synthase and marks endothelial dysfunction, which precedes plaque by years. TMAO is produced by gut bacteria from choline and carnitine and links the microbiome to arterial risk.
Read ADMA against kidney function — it is renally cleared and rises with impairment. For TMAO, standardise diet for 48 hours and avoid fish for 24, because fish raises it sharply without the same implication.
What to test next
Markers rarely answer alone. These are the ones that put ADMA & SDMA in context — each with its own full breakdown.
Frequently asked questions
ADMA 0.4–0.75 µmol/L; SDMA 0.3–0.7 µmol/L Ranges vary by laboratory and assay — always compare to the range printed on your own report.
Optimal ranges, root causes and the full correction protocol are available inside Coach Cam's Peptide Academy.
See the full breakdown inside the Academy.
See the full breakdown inside the Academy.
You can order ADMA & SDMA directly through Marek Diagnostics without a doctor's visit — drawn at any Quest Diagnostics location in the US. Code CAMERON applies 10% off automatically.