Betaine Anhydrous (TMG)
Best-in-class: Betaine Anhydrous
A methyl donor (trimethylglycine) that acts as a cellular osmolyte for power/strength output and lowers homocysteine for cardiovascular support.
How Betaine Anhydrous (TMG) actually works
Trimethylglycine does two things. It donates a methyl group to betaine-homocysteine methyltransferase, converting homocysteine back to methionine — a folate-independent route through the methylation cycle. Separately it is an osmolyte, accumulating inside cells to protect them against dehydration and thermal stress, which is the proposed basis for its performance effect.
Betaine Anhydrous (TMG) quick facts
| Suggested dose | 2.5 g daily. |
| How often | Daily |
| Who it's for | Strength/power athletes and methylation/cardiovascular support. |
✅ Clinically validated
- RCTs show improved power, strength and body composition with ~2.5 g/day in trained lifters.
- Lowers homocysteine as a methyl donor.
📊 Correlative data
- Betaine status supports methylation and cellular hydration under training stress.
🧪 Theoretical / extrapolated benefits
- Performance benefits are reasonably supported; mechanisms (osmolyte + methylation) are well-characterized.
These tiers tell you how much human evidence exists — not how well something works. This is the research space, and most of what’s in here is new rather than disproven. Something sitting at “theoretical” usually means nobody has funded the trial, not that the trial was run and failed.
The trap runs the other way too: something can be clinically validated and still do very little for you specifically. A statistically significant result in a study population is not a promise about your body.
- ✅ Clinically validated — human randomised trials or meta-analyses support it. The strongest footing available.
- 📊 Correlative — observational or epidemiological data. Suggestive, and genuinely useful for direction, but it cannot establish cause.
- 🧪 Theoretical / mechanistic — the mechanism is understood and often demonstrated in cells or animals, and the human trial doesn’t exist yet. Unproven is not the same as ineffective. Plenty of what’s standard practice today sat here five years ago.
✗ is a safety flag, not a grade. Where you see it, the concern is harm — not a disappointing trial. A compound tested for one purpose and found not to help there can still be worth studying somewhere else, so a negative result never gets rendered as a cross. It sits alongside the tier, because something can be both well-studied and genuinely risky.
My job is to tell you which one you’re looking at, and let you make the call. Grading something low isn’t me dismissing it — it’s me refusing to oversell it. This is the research space, and being able to reason forward from a mechanism matters as much as waiting for the trial.
Multiple resistance-training trials show improved power output and body composition at around 2.5 g daily, which is more consistent than most performance supplements manage. It is also the cheapest way to support methylation alongside folate and B12, and the reason it appears in NAD+ precursor stacks — heavy NMN or NR dosing consumes methyl groups. Do not confuse it with betaine HCl, which is a stomach acid supplement and a completely different thing despite the shared name.
Betaine Anhydrous (TMG) — safety & side effects
- GI upset and diarrhoea at higher doses. A fishy body odour in some people, again via trimethylamine.
- Raises total cholesterol and LDL in several trials — a real and reproducible effect that is worth knowing if you are managing lipids.
- Lowers homocysteine effectively, which is its main use. No major drug interactions.
Not medical advice. If you take prescription medication or have a diagnosed condition, check this against it with a pharmacist or doctor — pharmacists are underused and free.
Where to get Betaine Anhydrous (TMG)
Find Betaine Anhydrous (TMG) on iHerb →Get the complete breakdown for Betaine Anhydrous (TMG) — inside the Academy alongside the full interactive Vault.
Unlock in the Academy — $10/mo →- When to take it, and what to take it with
- Which form actually absorbs
- Who it's worth it for
- Best-in-class brand pick
- Coach Cam's stacks and notes
Get the complete breakdown for Betaine Anhydrous (TMG) — inside the Academy alongside the full interactive Vault.
Unlock in the Academy — $10/mo →Bloodwork to run alongside Betaine Anhydrous (TMG)
Run these before you start, and again after 8–12 weeks. A baseline you didn’t take is one you can never go back for.
| Marker | What it’s watching for |
|---|---|
| Homocysteine | TMG lowers it directly. This is the marker to prove it worked |
| Lipid Panel (Cholesterol, HDL, LDL, Triglycerides) | Trials show TMG can RAISE LDL — the part supplement pages leave out |
| ApoB (Apolipoprotein B) | The particle count, which matters more than the cholesterol number |
The Real Cardiovascular Risk panel covers these in one order — 9 markers, $187.60 with the discount applied.
Check results you already have → · All 102 markers A–Z
Betaine Anhydrous (TMG) — frequently asked questions
What is Betaine Anhydrous (TMG)?
A methyl donor (trimethylglycine) that acts as a cellular osmolyte for power/strength output and lowers homocysteine for cardiovascular support.
What is the suggested dose of Betaine Anhydrous (TMG)?
2.5 g daily. This is a general reference for education only — statements have not been evaluated by the FDA and this is not medical advice.
Where can I find Betaine Anhydrous (TMG) dosing and the full breakdown?
The suggested dose and the full evidence — clinical, correlative and theoretical — are on this page. What's inside the Academy is when to take it, which form actually absorbs, the brand worth buying and Coach Cam's stacks.
Where can I buy Betaine Anhydrous (TMG)?
Coach Cam sources Betaine Anhydrous (TMG) from vetted, top-rated brands on iHerb — use the buy link on this page.
Build your foundation with Coach Cam
The full Supplement Vault — 350 products across 14 categories with clinical, correlative & theoretical evidence, plus my Thorne partner links — lives inside the Academy alongside 237 peptides.
Join the Academy — $10/mo →What Betaine Anhydrous (TMG) is used for
Betaine Anhydrous (TMG) appears under 6 goals in the Vault’s goal router, grouped by the mechanism it works through rather than by how much trial evidence exists. Each link opens that pathway in full, with the alternatives beside it and the bloodwork that tests it.