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Brain Impact Support

Best-in-class: SynaQuell+

Cognitive & Mood✅ Clinically validated📊 Correlative data🧪 Theoretical

Thorne SynaQuell, the formula currently on the market. Per scoop the filed panel declares L-leucine 1.25 g, L-isoleucine 625 mg, L-valine 625 mg, beta-hydroxybutyrate 500 mg, reduced glutathione 250 mg, nicotinamide riboside hydrogen malate 207.5 mg, Meriva curcumin phytosome 125 mg, trans-resveratrol 125 mg, DHA 125 mg from algal oil, magnesium 59 mg, Ubiqsome coenzyme Q10 phytosome 50 mg, betaine anhydrous 42.5 mg and riboflavin 25 mg. There is no HydroCurc in it, no EPA, no choline and no ginkgo. The bigger SynaQuell+ formula was withdrawn in June 2025.

Educational use only — not medical advice. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Brain Impact Support quick facts

Suggested doseAs directed, particularly around contact-sport seasons.
How oftenDaily, particularly through contact-sport seasons
Who it's forContact/collision-sport athletes and those wanting structural brain support.
Coach Cam’s take

The secondary-cascade rationale is sound and the doses reflect research protocols rather than general wellness levels, which is unusual and to its credit. Human outcome evidence in concussion remains limited. It is supportive care rather than treatment, and it should never displace proper medical assessment after a head injury.

How Brain Impact Support actually works

Built around the secondary injury phase, which unfolds over days to weeks after a head impact and is the part that is theoretically modifiable. The filed formula puts 2.5 g of branched-chain amino acids and 500 mg of beta-hydroxybutyrate against the energy crisis, 125 mg of DHA against membrane damage, and reduced glutathione, a Meriva curcumin phytosome and trans-resveratrol against the oxidative and inflammatory cascade. The omega-3 here is DHA alone, at a fraction of the gram doses the traumatic brain injury literature uses, and there is no creatine in it.

⚠️ Good to know: Support, not protection from injury — it doesn't prevent concussions; it supports the brain's nutritional foundation.

Where to get Brain Impact Support

Buy SynaQuell+ at Thorne →
10% off auto-applied at checkout · Coach Cam partner link

The evidence for Brain Impact Support

Graded by what exists behind each claim.

✅ Clinically validated

📊 Correlative data

🧪 Theoretical / extrapolated benefits

How to read these tiers: they say how much human evidence exists, not how well something works — and ✗ flags harm, never a disappointing trial. How the evidence tiers work →

What Brain Impact Support actually does

Before any mechanism, the label — because the card above and the filed Supplement Facts panel are not describing the same product. Per one 11.9 g scoop of SynaQuell+, as filed with the NIH Dietary Supplement Label Database: riboflavin 100 mg as riboflavin 5'-phosphate sodium; magnesium 220 mg, from 132 mg of magnesium bisglycinate chelate and 88 mg of magnesium beta-hydroxybutyrate; L-leucine 1.25 g, L-isoleucine 625 mg and L-valine 625 mg; beta-hydroxybutyrate 750 mg; reduced glutathione 500 mg; nicotinamide riboside hydrogen malate 415 mg; docosahexaenoic acid 375 mg from algal oil; Meriva curcumin phytosome 250 mg; trans-resveratrol 125 mg; betaine anhydrous 85 mg; and Ubiqsome coenzyme Q10 phytosome 50 mg NIH DSLD 323088. That is the entire active formula.

Four things in it contradict the card. There is no HydroCurc — the curcumin is Meriva, a different manufacturer's phospholipid complex NIH DSLD 323088 Cuomo 2011. “Omega-3s” is DHA alone, from algae, with no EPA. The only botanical-derived actives are curcumin and resveratrol. And the card's own safety note tells the reader to watch for stacking choline sources and for ginkgo affecting clotting: this product contains neither choline nor ginkgo.

The fifth is larger. That label is off market. SynaQuell+ is recorded as withdrawn on 17 June 2025 NIH DSLD 323088. The SynaQuell currently filed as on market is a different formula at a smaller serving: riboflavin 25 mg, magnesium 59 mg entirely from magnesium beta-hydroxybutyrate with no bisglycinate, beta-hydroxybutyrate 500 mg, reduced glutathione 250 mg, nicotinamide riboside hydrogen malate 207.5 mg, DHA 125 mg, Meriva 125 mg, trans-resveratrol 125 mg, betaine anhydrous 42.5 mg, Ubiqsome 50 mg, and the same 2.5 g of branched-chain amino acids NIH DSLD 337875. Resveratrol, coenzyme Q10 and the amino acids are unchanged. Everything else was cut: nicotinamide riboside, glutathione, Meriva and betaine to half, DHA to a third, magnesium to 27%, and riboflavin to a quarter. If you bought this product on its ingredient list, the list is not the one you bought.

The mechanisms, one line each, and they are five different arguments rather than one. DHA is structural: it is the dominant long-chain polyunsaturated fatty acid of neuronal and synaptic membranes, and the animal rationale behind this product is axonal. Beta-hydroxybutyrate is a fuel: it crosses the blood-brain barrier on monocarboxylate transporters and is oxidized in place of glucose, which is the argument for ketones after a head impact, when cerebral glucose metabolism is depressed. Riboflavin is a mitochondrial flavoprotein cofactor whose clinical home is migraine prophylaxis Schoenen 1998 Thompson 2017. Nicotinamide riboside is an NAD precursor entering past the rate-limiting classical salvage enzyme Martens 2018. Betaine is one enzyme, betaine-homocysteine methyltransferase Steenge 2003. Nothing in that list is cholinergic and nothing in it is a nootropic in the usual sense.

Cell, rodent, human — and where it stops

DHA, and this is the only ingredient with a trial in the right population and the right endpoint. Eighty-one NCAA Division I American football athletes were randomized, double-blind, to 2, 4 or 6 g/day of DHA or placebo across 189 days of a season, with blood sampled at times matched to changes in contact load. Plasma DHA rose dose-dependently. Serum neurofilament light — a biomarker of axonal injury — rose more in starters, area under the curve 1,995 plus or minus 1,383 pg/mL, than in non-starters, 1,398 plus or minus 581 pg/mL, p = 0.024. Irrespective of dose, DHA likely attenuated the rise in neurofilament light, at small to moderate effect sizes of 0.4 to 0.7 by standardized magnitude-based inference Oliver 2016.

Now the arithmetic that decides this product. The lowest arm of that trial was 2,000 mg of DHA per day. The SynaQuell+ scoop carries 375 mg NIH DSLD 323088; the product currently on the market carries 125 mg NIH DSLD 337875. That is between a fifth and a sixteenth of the smallest dose that has ever been tested against this endpoint, in the sport this product was built for.

Riboflavin. Migraine prophylaxis is established at 400 mg per day Schoenen 1998 Thompson 2017. The “+” scoop has 100 mg and the current one 25 mg NIH DSLD 323088 NIH DSLD 337875. Riboflavin absorption is saturable, so a large single oral dose is only partly absorbed Zempleni 1996 — which is an argument for splitting a dose, not for taking a quarter of one.

Nicotinamide riboside. Chronic supplementation was well tolerated and raised NAD in healthy middle-aged and older adults Martens 2018; 1,000 mg/day for 30 days raised cerebral NAD in 30 newly diagnosed, treatment-naive Parkinson's patients Brakedal 2022, with a higher-dose safety trial after it Berven 2023. The scoop declares 415 mg of a hydrogen malate salt NIH DSLD 323088, and a salt weight is not a base weight.

Betaine. Six grams a day lowers plasma homocysteine in healthy men and women Steenge 2003. Eighty-five milligrams is 1.4% of that dose; 42.5 mg is 0.7% NIH DSLD 337875.

The rest, briefly. Meriva is a lecithin delivery system developed specifically because curcumin is poorly absorbed, and the comparative absorption study is what justifies its price Cuomo 2011, with the joint-symptom literature sitting on curcumin generally Daily 2016. Resveratrol has high oral absorption and very low bioavailability because it is almost completely conjugated on first pass Walle 2004 Boocock 2007. Oral glutathione's absorption is contested: the tripeptide is normally cleaved and resynthesized inside cells from cysteine Lu 2013, and the trial evidence that oral dosing can raise body stores comes from a liposomal formulation Sinha 2018 rather than the plain reduced glutathione on this label NIH DSLD 323088. Magnesium's own mood and stress literature is mixed Boyle 2017.

The obstacle, in one sentence. Not one ingredient in this product has been tested at the dose it is present at against a concussion, subconcussive-impact or recovery outcome, and the single trial that used the right population and the right biomarker used DHA alone at 2 to 6 grams Oliver 2016. NSF Certified for Sport NIH DSLD 337875 is a statement about banned substances and manufacturing control, not about efficacy.

Brain Impact Support — which form, and does it matter

Salt and complex questions are doing real work in this product, and the label resolves almost none of them.

Riboflavin 5'-phosphate sodium rather than riboflavin: the phosphate is dephosphorylated by intestinal alkaline phosphatase before absorption, so it is a solubility and taste choice for a powder rather than a bypass of anything Zempleni 1996.

Nicotinamide riboside hydrogen malate rather than the chloride used in every human trial Martens 2018 Brakedal 2022 Berven 2023: a different counter-ion means a different quantity of nicotinamide riboside inside the same declared 415 mg NIH DSLD 323088, and the label does not state the difference. Anyone comparing this to the 1,000 mg used in the Parkinson's trial is comparing one salt weight to another.

Magnesium beta-hydroxybutyrate is doing two jobs at once, supplying part of the magnesium and part of the ketone. The current formula dropped the bisglycinate chelate entirely NIH DSLD 337875, which changes both the absorption profile and the gastrointestinal tolerability of the magnesium, and reduces total magnesium from 220 mg to 59 mg.

Meriva and Ubiqsome are phytosomes, and the milligrams on the label are milligrams of the phospholipid complex, of which the active is a fraction Cuomo 2011. Two hundred and fifty milligrams of Meriva is not 250 mg of curcuminoids, and no label in this category makes that clear.

Reduced glutathione, not liposomal. The randomized evidence that oral glutathione raises body stores used a liposomal preparation Sinha 2018; this label declares plain reduced glutathione NIH DSLD 323088 NIH DSLD 337875, which is the form with the hardest absorption argument Lu 2013.

DHA from algal oil is the same molecule as fish-derived DHA with no EPA alongside it, and it is a legitimate and deliberate choice for a vegetarian athlete — but a product described as “omega-3s” that contains one omega-3 is under-describing itself NIH DSLD 323088.

And the form question to settle first: which SynaQuell is on the shelf. The card names SynaQuell+, which is off market as of 17 June 2025 NIH DSLD 323088. What is currently filed as on market is a different formula at roughly half the dose of most shared ingredients NIH DSLD 337875.

What would have to be true, and how you would know it was not

1. The omega-3 index is the honest read-out, because it is the one ingredient with a trial. It is a standardized red blood cell measurement, it is orderable, and red cell fatty acid turnover takes roughly three months — so draw it before starting and again at 12 weeks. Predict a rise of one to two percentage points on 375 mg/day of DHA and a smaller one on 125 mg, and predict that neither approaches the exposure produced by the 2 to 6 grams a day used in the football trial Oliver 2016 NIH DSLD 323088 NIH DSLD 337875.

2. Homocysteine, because two ingredients touch it. Fasting plasma homocysteine at day 0 and week 12. Betaine lowers it at 6 g/day Steenge 2003 and riboflavin is the flavin cofactor for the MTHFR enzyme. Predict no change, because 85 mg of betaine is 1.4% of the dose that moves it NIH DSLD 323088. A fall would be a genuine finding and would need a different explanation.

3. The prediction that cuts against the product. Predict that whole-blood NAD rises and that nothing you can score neurologically does. Nicotinamide riboside raises NAD reliably Martens 2018, and a biomarker that moves while the outcome does not is the characteristic failure mode of this entire shelf. If the only thing your money buys is a number in a research assay, that is worth knowing.

4. If you are a contact-sport athlete, serum neurofilament light is now clinically available, and it is the exact endpoint of the trial this product is built on Oliver 2016. Draw it pre-season and at season's end. Predict that it rises with contact load whatever you take, because it rose in every arm of that trial and the DHA effect was an attenuation of the rise, not a prevention of it.

What will fool you: the NSF Certified for Sport mark NIH DSLD 337875. It certifies that the tub contains no banned substance and that the label is accurate. It says nothing about whether the doses do anything, and it is very easy to read a quality certification as an efficacy claim.

What nobody has tested yet

Nobody has tested this formula. There is no randomized trial of SynaQuell or SynaQuell+ against placebo on any concussion, subconcussive-impact, symptom or recovery endpoint, and these thirteen declared actives have never been given together in a published study NIH DSLD 323088 NIH DSLD 337875. Every number on this page belongs to one component at a different dose.

Nobody has tested DHA below 2 g/day against neurofilament light. The dose-finding trial started at 2,000 mg and could not separate 2, 4 and 6 g Oliver 2016. Whether 375 mg does anything to an axonal injury biomarker is an open, cheap and directly relevant question, and it is the one this product most needs answered.

Nobody has measured cerebral ketone uptake from 750 mg of an oral beta-hydroxybutyrate salt. The transport biology is established; whether that quantity moves brain ketone metabolism measurably in a human has not been published, and it is an arteriovenous difference study or a PET scan.

Nobody has run the reformulation as an experiment. The market has just performed a natural halving of most of the doses NIH DSLD 323088 NIH DSLD 337875. Comparing the two products head to head on any endpoint would be the single most informative study anybody could run on this shelf, and the material for both arms already exists.

Brain Impact Support — its own safety story, not its category's

The first safety statement on this page is a correction. The card's own note asks the reader to watch for multiple choline sources stacking and for ginkgo affecting clotting. This product contains no choline and no ginkgo NIH DSLD 323088 NIH DSLD 337875. A warning about ingredients that are not in the bottle is worse than no warning, because it spends the reader's attention on the wrong risk and teaches them to skim the next one.

What the real risks are, ingredient by ingredient. Riboflavin at 100 mg is harmless and turns urine bright yellow within hours; anybody not told will think something is wrong. Magnesium at 220 mg is a laxative dose for some people, and the current formula's magnesium comes entirely from the beta-hydroxybutyrate salt NIH DSLD 337875, which is a different tolerability profile from the bisglycinate it replaced. Two and a half grams of branched-chain amino acids is a protein and nitrogen load rather than a neurological ingredient, and it belongs in a training decision rather than a brain one.

Curcumin is the ingredient with a real interaction. It has antiplatelet activity and a rare but documented hepatotoxicity signal, and it sits in a product aimed at athletes who are frequently also taking non-steroidal anti-inflammatories Cuomo 2011 Daily 2016. Anyone on an anticoagulant or antiplatelet drug should treat 250 mg of a high-absorption curcumin as an active drug rather than a spice.

Resveratrol carries an unusual and specific caution for this audience. In aged men, resveratrol supplementation blunted several of the cardiovascular adaptations that exercise training would otherwise produce Gliemann 2013. One hundred and twenty-five milligrams is a modest dose and the finding is not universally replicated, but an athlete taking a training-adaptation supplement should know that one of its ingredients has been shown to work against training adaptation.

Nicotinamide riboside has a good tolerability record at doses well above the amount here Martens 2018 Berven 2023.

The category risk is behavioral and it is the most important sentence on the page. This is sold to people who take repeated head impacts, and no supplement prevents a concussion. The card says so, and it is right. A product that makes an athlete feel protected changes behavior on the field and in the medical tent, and behavior is what actually determines head-impact exposure and how quickly an injury is reported.

Who should not take it: anyone on an anticoagulant or antiplatelet drug, because of the curcumin Cuomo 2011 Daily 2016; anyone with active liver disease; anyone pregnant, where several of these ingredients have no data; any athlete in a tested sport who has not confirmed the certification on the tub they actually bought NIH DSLD 337875; and any athlete who would take it instead of reporting a head injury.

Sources read for this page

How you would know if it worked

There is no blood test for this one. That is not a criticism — it is a fact about the effect, and it changes how you should judge it.

Run it one variable at a time. Starting three things in one week means a result you cannot attribute, which is the same as no result.

Brain Impact Support — safety & side effects

Standing advice — multi-ingredient formulas

The same on every page it applies to. Read it here; it is not repeated research.

  • This is one formula with several actives, and it carries the combined safety profile of everything on its panel — the risks do not average out, they add. Check the panel above against anything else you take, because the commonest way to overdose an ingredient is to meet it twice in one day under two different product names.

Not medical advice. If you take prescription medication or have a diagnosed condition, check this against it with a pharmacist or doctor — pharmacists are underused and free.

🔒
The dose is the easy part. Making Brain Impact Support actually work is what's behind Skool:
Running it
  • When to take it, and what to take it with
  • Which form actually absorbs
  • Who it's worth it for
  • Best-in-class brand pick
  • Coach Cam's stacks and notes
When to take it
  • Fasted or with food, and when in the day
  • Morning or night, and why that window
  • Around training, or deliberately away from it
  • What it must not share a window with

Everything above is free and stays free. Skool is where it becomes a plan — Brain Impact Support in an order, with the rest of what you're running.

Unlock in Skool — $10/mo →

Bloodwork to run alongside Brain Impact Support

Baseline first, then again at 8–12 weeks.

MarkerWhat it’s watching for
TSH (Thyroid-Stimulating Hormone)Thyroid disease imitates every cognitive complaint there is
Vitamin B12Deficiency causes fog long before it causes anemia
Methylmalonic Acid (MMA)Catches the deficiency a normal B12 hides
FerritinLow iron flattens cognition at levels most labs call fine
Vitamin D (25-Hydroxy)Commonly low, cheap to correct, associated with mood

The Brain Fog & Cognition panel covers these in one order — 12 markers, $233.06 with the discount applied.

Check results you already have → · All 103 markers A–Z

Brain Impact Support — frequently asked questions

What is Brain Impact Support?

Thorne SynaQuell, the formula currently on the market. Per scoop the filed panel declares L-leucine 1.25 g, L-isoleucine 625 mg, L-valine 625 mg, beta-hydroxybutyrate 500 mg, reduced glutathione 250 mg, nicotinamide riboside hydrogen malate 207.5 mg, Meriva curcumin phytosome 125 mg, trans-resveratrol 125 mg, DHA 125 mg from algal oil, magnesium 59 mg, Ubiqsome coenzyme Q10 phytosome 50 mg, betaine anhydrous 42.5 mg and riboflavin 25 mg. There is no HydroCurc in it, no EPA, no choline and no ginkgo. The bigger SynaQuell+ formula was withdrawn in June 2025.

What is the suggested dose of Brain Impact Support?

As directed, particularly around contact-sport seasons. This is a general reference for education only — statements have not been evaluated by the FDA and this is not medical advice.

Where can I find Brain Impact Support dosing and the full breakdown?

The suggested dose and the full evidence — clinical, correlative and theoretical — are on this page. What's inside Skool is when to take it, which form actually absorbs, the brand worth buying and Coach Cam's stacks.

Where can I buy Brain Impact Support?

Coach Cam sources Brain Impact Support from Thorne, with 10% off auto-applied at checkout — use the buy link on this page.

What Brain Impact Support is used for

Brain Impact Support appears under 1 goal in the goal router.

🧠 Focus, memory & cognitionNeuroinflammation & membrane integrity
AshwagandhaL-5-HTPPharmaGABABrain SupportAcetyl-L-CarnitinePhosphatidylcholinePanax GinsengMood Support

Where this goes next

In contextNeuroinflammation & membrane integrityThe focus, memory & cognition pathway Brain Impact Support belongs to
Go deeper$10/mo

The pages here are the frameworks. The protocols — the dosing, the order to correct things in, the week-by-week schedule and what to retest — are inside Skool.

Every protocol on the site

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