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The Sleep Blueprint

8 weeks, four arms, one pick each

4pathways, one pick each
24options to swap or stack
8week schedule
9markers to draw first

Everything on this page is free. The stack, why each pick beat its alternatives, every option, the bloodwork and the safety lines. The week-by-week schedule and the decision rules are the members half.

Built on 237 compounds and 350 supplements · 1,469 members · 92% stay past month one

Onset, maintenance, depth and rhythm are four different problems with four different answers, and treating them as one is why most sleep supplements disappoint. If you cannot fall asleep, that is an onset problem. If you fall asleep fine and wake at 3am, that is maintenance — and it is very often blood sugar or cortisol rather than anything sleep-specific. If you sleep eight hours and wake unrefreshed, that is depth. If you are tired at the wrong times entirely, that is rhythm. Name which one you have before buying anything. The fourth arm exists because the most common cause of bad sleep is not a sleep problem at all.

Research protocol

This is a theoretical research protocol written for the research community. The compounds below are supplied for research purposes and are not approved medicines — several are not approved for human use in any jurisdiction. Nothing here is medical advice, a prescription, or a recommendation for human use, and it has not been evaluated by the FDA. Full disclaimer & affiliate disclosure →

Who this is forAnyone. Sleep sits upstream of every other goal on this site — the fat-loss, muscle, cognition and longevity blueprints all assume it is handled, and none of them work properly if it is not.
How these combine

Can you run all of them? Not this time - and here is why

These do not simply add up. Several are sedating and the sedation stacks - four at once is how people end up groggy at 10am rather than asleep at 11pm. The onset, depth and rhythm arms combine well. Stacking multiple GABAergics is the specific combination to avoid.

This is a general protocol. You make the final call on how much of it to run — or have it built around your labs.

Start here

Which of these 4 is actually you?

This tells you where your biggest leverage is — where to start, not where to stop. Read the But line too: it is what each lane cannot do for you, which is the part a list of options never tells you.

1
Sleep onset — GABAergic & sedative
You lie there. Once you are under you stay under, but the first hour is the fight.
But Sedation is not sleep architecture. The strong options here build tolerance and some build dependence.
2
Circadian & melatonergic rhythm
You sleep fine — at the wrong times. Weekends drift late and Monday is brutal.
But Dose and timing matter far more than most people think, and more melatonin is reliably worse than less.
3
Sleep depth, slow-wave & recovery quality
You get eight hours and wake unrefreshed. The duration is not the problem.
But If you snore or wake gasping, no compound in this lane helps — that is apnoea and it needs a test.
4
What's keeping you awake — the upstream causes
You wake at 3am, reliably, and cannot explain it.
But The answer here is usually glucose, alcohol, iron or hormones — so the fix is rarely a sleep supplement at all.

Before any of it — the foundation

These four are not a disclaimer at the bottom of the page. They are the reason the rest of it works, and every one of them is free.

Sleep — 7–9 h, consistent timing

Growth hormone is released in pulses during deep sleep, insulin sensitivity is measurably worse after one bad night, and appetite regulation collapses without it. Every compound below works through a system that sleep already governs. This is not filler advice — it is the highest-leverage item on the page and it is free.

Protein — 1.6–2.2 g/kg bodyweight daily

The single dietary variable with the most consistent evidence behind it for body composition, in both directions — building and preserving. Under-eating protein while running anything anabolic is paying for a signal with no substrate to act on.

Resistance training — 3–4 sessions weekly, progressive

Nothing here substitutes for mechanical tension. Compounds change how well you recover from and adapt to training; they do not replace the stimulus. A protocol run without training reliably produces the side effects and not the results.

Steps — 8,000–12,000 daily

Non-exercise activity is the largest and most variable component of daily energy expenditure, and it is the one that quietly falls when you start dieting. Tracking it stops the metabolic adaptation people blame on their thyroid.

The stack

How to read thisFour arms, and you want the one matching your actual problem. Running all four is how people end up groggy — several of these are sedating and the effects add. Start with arm four if anything in it applies to you. Fixing the cause beats managing the symptom, and it is the arm nobody starts with.
On the evidence

Said once. This goal has better evidence than most on the site — glycine, melatonin, magnesium and l-theanine all have real randomised data. The peptide options are more speculative and are labelled as such. Unproven is not the same as ineffective, and each item's page carries its full evidence tier.

Each pick names what it was chosen over and why. That is the difference between a blueprint and a list — if you disagree with a choice, the alternative is right there and swapping it does not break the rest.

Section 1.1

Peptides 2

Short amino-acid chains that signal rather than force. Almost all are injected or intranasal, they need reconstituting, and they are the reason most people are on this site.

Circadian & melatonergic rhythm
Delta Phase Matrix
The rhythm arm

*'Add Delta Phase Matrix... I'd prefer it to be the primary option over melatonin.'* DSIP, melatonin, GABA and pinealon in one intranasal - it covers onset, depth and rhythm where melatonin alone only shifts the rhythm.

Start here for shift work, jet lag or a shifted clock
0.5–1 mg, 2–3 h before target bedtime
The other lanes in this arm

Tart cherry contains a small natural amount plus anthocyanins. Epitalon and Pinealon act on the pineal gland — the argument is restoring the rhythm rather than supplying the hormone. DSIP acts on sleep architecture. Delta Phase Matrix is a blend of that approach. Melatonin is the base because it is the actual signal, it is cheap, and it is the one where using it correctly changes the result more than switching product ever would.

Stack this arm deeper7 optional add-ons

Each of these sits in this same pathway, so it starts the week this pathway starts. Swapping one in for the pick above does not change the schedule.

Melatonin

The previous pick for this arm, kept as an option. Melatonin is a timing signal, not a sedative — and almost everyone uses it wrong. It tells your body clock that night has started. That means the dose is far smaller than sold (0.3–1 mg is physiol

The trade-off Cam moved it out of the lead spot on sign-off; the reasoning for its replacement is above.

Epitalon

A Khavinson tetrapeptide reported to normalise pineal function and melatonin rhythm — restoring the system rather than supplementing its output.

The trade-off Run as short courses, once or twice a year, not continuously. The evidence base is largely one research group's and rarely replicated independently.

DSIP

Delta sleep-inducing peptide — acts on sleep ARCHITECTURE rather than onset or timing. Aimed at the depth of sleep you get.

The trade-off Genuinely hit or miss between people. Some sleep like a rock, some feel nothing at all, and there is no way to predict which you are.

Tart Cherry

A food source of melatonin plus anthocyanins — the trials used concentrate and measured both sleep duration and recovery markers in athletes.

The trade-off Far less melatonin than a tablet, and it comes with sugar. Its value is the recovery half rather than the dose.

L-Tryptophan

Upstream substrate for both serotonin and melatonin, so the body's own regulation stays in the loop rather than being overridden by an exogenous dose.

The trade-off Competes with other amino acids for brain entry, so it works better away from protein. Serotonergic — the SSRI warning applies.

Pinealon

A pineal bioregulator aimed at the gland that makes melatonin, rather than at supplying the hormone. Ten days on, months off.

The trade-off One research group's evidence, mostly in Russian. A completely different evidence class from everything else in this arm and stated as such.

Vitamin B6 (P5P)

The cofactor converting 5-HTP to serotonin and onward to melatonin — a bottleneck rather than a booster, which is why it matters most alongside tryptophan.

The trade-off Above 100 mg daily long-term causes peripheral neuropathy. This is the one B vitamin with a real ceiling.

Sleep depth, slow-wave & recovery quality
CJC No Dac/Ipamorelin
5 options
The depth arm
How often1-3x Daily AM/Workout/PM · 5 On 2 Off or Daily
What the mechanism allowsFollow the protocol — more often is worse, not better
The effect depends on hitting the receptor intermittently, not on holding a level. Continuous exposure downregulates it. The short half-life is the feature, and dosing more often than the protocol says makes it work less, not more. Tested at: 5 On 2 Off or Daily. The half-life here is a red herring: it is short because the pulse is the point.
5 options — 2 to swap in, 3 to stack ontap to collapse
MK-677Swap in
Orally active ghrelin-receptor agonist / GH secretagogue — sustains elevated GH and IGF-1 around the clock.
How often1x Daily Anytime
SermorelinStack on
Truncated GHRH analog — stimulates pituitary GH release; the gentlest, most physiologic of the GHRHs.
How often1-2x Daily AM/PM · 5 On 2 Off or Daily
IpamorelinSwap in
Selective ghrelin/GHSR agonist — triggers a GH pulse with minimal cortisol or prolactin bump.
How often1-3x Daily AM/Workout/PM · 5 On 2 Off or Daily
ReishiGanoderma lucidumStack on
An adaptogenic 'calming' medicinal mushroom used for sleep, stress and immune balance.
How oftenDaily
ZincBisglycinate / PicolinateStack on
Essential trace mineral critical for immune function, wound healing, testosterone metabolism, taste/smell, and hundreds of enzymes.
How oftendaily
Sedation is not sleep, and stacking sedatives is the mistake this goal invites. Several options here are mildly sedating, and the effects add. Two or three together produces next-day grogginess that people then treat with more caffeine, which pushes bedtime later and makes the original problem worse. That loop is extremely common. And nothing here works around alcohol. It shortens sleep onset and then destroys the second half of the night — suppressed REM, fragmented slow-wave, a 3am waking. If you drink in the evening, that is the intervention, and no compound on this page competes with it. Same for light: bright light in the two hours before bed suppresses your own melatonin. Taking melatonin while sitting under it is paying to undo something you are still doing.
Section 2

Health supplements & substrate

The floor underneath the compounds. Cheap, well tolerated, and the part that decides whether anything above it has a fair chance — a secretagogue on a magnesium deficiency is a rounding error.

Sleep onset — GABAergic & sedative
Glycine
6 options
The onset arm
How oftenDaily
6 options — 2 to swap in, 4 to stack ontap to collapse
L-TheanineFree-form amino acidStack on
A calming amino acid from green tea that promotes relaxed focus by raising alpha brain waves — without sedation.
How oftenas needed
Magnesium L-ThreonateMagteinStack on
The one magnesium form shown to cross the blood-brain barrier and raise brain magnesium — prized for sleep, memory and cognition specifically.
How oftenDaily
MagnesiumBisglycinate (chelated)Stack on
An essential mineral and cofactor for 300+ enzymatic reactions.
How oftendaily
ApigeninFlavonoid (chamomile-derived)Stack on
A flavonoid (the calming compound in chamomile) that binds benzodiazepine/GABA sites to ease into sleep, with additional antioxidant and NAD-sparing interest.
How oftenDaily
Magnolia BarkHonokiol/magnololSwap in
A calming botanical (honokiol/magnolol) that eases stress and cortisol and supports sleep — a key ingredient in many cortisol/sleep formulas.
How oftenDaily
ValerianRoot extractSwap in
A traditional sleep-and-calm botanical that gently supports GABA activity to ease the transition into sleep.
How oftennightly
What's keeping you awake — the upstream causes
Ashwagandha
6 options
The upstream-cause arm
How oftendaily
6 options — 0 to swap in, 6 to stack ontap to collapse
PhosphatidylserineIso-PhosStack on
A key brain-cell-membrane phospholipid that supports memory, focus and — notably — blunts exercise- and stress-induced cortisol spikes.
How oftendaily
Myo-InositolStack on
A B-vitamin-like compound and insulin second-messenger with strong evidence for PCOS, insulin sensitivity, and — at higher doses — anxiety and mood.
How oftenDaily
Holy Basil (Tulsi)Ocimum sanctumStack on
An adaptogenic herb for stress, mood and balanced cortisol, with bonus blood-sugar and immune support.
How oftenDaily
BerberineHCl (500 mg)Stack on
A plant alkaloid that activates AMPK — the same energy-sensing pathway as exercise and metformin — with powerful effects on glucose and lipid metabolism.
How oftendaily
IronBisglycinateStack on
Essential for hemoglobin, oxygen transport and energy.
How oftenevery other day
Perimenopause SupportPerimenopause CompleteStack on
A women's blend targeting the hormonal transition — supporting mood, sleep, hot-flash comfort and hormone metabolism during perimenopause.
How oftenDaily

The 8-week schedule

What goes in, what comes out, and when. The exact doses for each phase are inside the Academy — the structure below is free because it is the part you need to decide whether this fits your life.

1–23–45–89+Ongoing
Glycine
Ashwagandha
CJC No Dac/Ipamorelin

Each bar is a week block that compound is running. The shape is free — it is what tells you whether this fits your life. The doses for each phase are the members half.

Weeks 1–2
Behaviour first, one compound

Fix the free variables and add one thing so you can attribute the result.

Consistent wake time, morning daylight, no alcohol, and dim light for two hours before bed. These outperform everything below and cost nothing. A compound on top of bad light hygiene is a compound fighting your own behaviour.

Weeks 3–4
Hold - the adaptogen arm is still loading

Nothing new. Ashwagandha moved to week 1 because its cortisol trials run eight weeks, which is the whole protocol - there is no room to start it late.

Can't fall asleep → onset. Wake at 3am → upstream causes. Unrefreshed after 8 hours → depth. Tired at the wrong times → rhythm. Adding the wrong arm produces nothing and teaches you nothing.

Weeks 5–8
Depth, if the first two did not do it

Restoration rather than duration.

Judge this on how you feel on waking, not on hours slept. If a tracker says your deep sleep improved but you feel the same, trust the feeling — consumer sleep staging is not accurate enough to overrule it.

Weeks 9+
Keep what earned it

Drop anything that did not change how you feel on waking.

Ashwagandha is not a forever compound — blunting cortisol continuously is not obviously desirable, and some people report emotional flatness over months. Glycine and the behavioural changes can run indefinitely.

Weeks Ongoing
Keep the architecture, drop the props

Sleep aids should get less necessary, not more.

Tolerance is the failure mode of this whole page. If you need more of something to get the same night, that is a signal to come off it rather than escalate. The behavioural work — fixed wake time, morning light, no alcohol within three hours — outperforms everything above and does not tolerate.

The doses for each phase are inside

Every compound above, dosed week by week, plus the reconstitution numbers and Coach Cam's notes on running it. $10/mo.

Unlock the schedule →

Bloodwork

This panel is here to catch the causes that are not sleep problems, which is most of them. Fasting insulin and HbA1c matter because a nocturnal glucose dip triggers adrenaline and wakes you — the classic reliable 3am waking. Thyroid because both directions disturb sleep, in different ways. Ferritin because restless legs is strongly associated with low iron stores well before anaemia shows up, and it is commonly missed in women. Morning cortisol, drawn at the same time on both occasions, gives you the stress axis. One thing no blood test will find: sleep apnoea. If you snore, wake gasping, or feel unrefreshed no matter what you do, that is a sleep study — and it is the single most under-diagnosed cause on this page.

Before you start

Everything, drawn before you start. This is the one that decides which pathway is actually yours - and the only one you cannot go back and collect later.

Fasting InsulinHbA1c (Hemoglobin A1c)TSH (Thyroid-Stimulating Hormone)Free T3 (Triiodothyronine)Free T4 (Thyroxine)FerritinVitamin D (25-Hydroxy)Cortisol (AM)Comprehensive Metabolic Panel (CMP)
Order the Baseline panel →9 markers · about $111 at list · code CAMERON auto-applies

Around week 8

The short list, drawn while you are running it. Not a progress report - it is the draw that catches the things that go wrong quietly.

Fasting InsulinCortisol (AM)
Order the Mid-cycle safety check panel →2 markers · about $22 at list · code CAMERON auto-applies

After

Drawn at the end, against your own baseline. This is what turns the protocol into information rather than a feeling.

Fasting InsulinHbA1c (Hemoglobin A1c)Cortisol (AM)Ferritin
Order the Re-test panel →4 markers · about $40 at list · code CAMERON auto-applies

All three are drawn at Quest, 2,000+ US locations, no doctor visit, HSA/FSA eligible. Prefer to pick and choose? Every marker above links to its own page, and the panel builder assembles any combination.

Adjusting it

A protocol you cannot adjust is a protocol you abandon. Four situations come up on nearly every run of this — nausea that will not settle, a three-week stall, hair shedding, glucose moving the wrong way. Each one has a specific answer, and the wrong answer to a stall is the reason most people end up on six compounds that each do nothing.

The four decision rules are inside

What to change, what to leave alone, and how to tell a real stall from a water shift. $10/mo.

Unlock the decision rules →

The lines I'd stop at

This is a general protocol, and that is deliberate.

It is built for the common case, not for you specifically. Compound selection and dosing genuinely do change person to person — training age, bloodwork, what you have run before, what you react to. Adjust it against your own numbers using the panels above, or if you want it built around your labs rather than the average, that is what 1-on-1 coaching is for.

See every option for this goal → · Open the Vault