🧠 Cognitive Decline & Alzheimer's Risk

For everyone · 9 markers · $608.36 with code CAMERON ~~$675.95~~

Family history of dementia, noticeable memory change, or you want the earliest possible read on brain health while there's still time to act.

🩸 Order this exact panel — 10% off

All 9 markers load into your cart in one click. No doctor's visit, drawn at any Quest location in the US, results by email in about two weeks. Code CAMERON applies automatically.

Add all 9 markers — $608.36 → Open the full Bloodwork Vault →

Why this panel

Alzheimer's pathology begins roughly two decades before symptoms. Blood-based markers that were research-only a few years ago can now detect it — and several contributors to cognitive decline are entirely reversible.

💡 What most people missTest the reversible causes before the irreversible one. B12 deficiency, hypothyroidism and severe sleep apnoea all produce memory complaints that fully resolve when treated, and they are far more common than early Alzheimer's — this panel covers them first for that reason. On the newer marker: pTau-217 is the standout blood test of the last few years for Alzheimer's pathology, performing remarkably well against amyloid PET and spinal fluid, and it is genuinely a different category of test from anything else here. Understand what a positive means before you order it: it indicates pathology, not a diagnosis, and this is a result worth receiving alongside a clinician rather than alone in your inbox.

⏰ When to get it drawnFast 9–12 hours, morning. Off B12 supplements 1 week if you want a true B12 reading.

What's inside

This panel covers 9 markers chosen for this specific situation. The full list, the clinical reasoning behind each marker, draw timing and how to interpret your results are available to Academy members.

🔒 Panel and protocol are inside the Academy

Every marker and why it's here — plus the full evidence-graded Cognitive Decline & Alzheimer’s Risk protocol: the reversible causes that are far more common than early Alzheimer’s and should be excluded first, what a raised pTau-217 actually means (and doesn’t), why APOE deserves a decision before the draw, and the 14 modifiable risk factors. $10/mo, cancel anytime.

Unlock the full panel →

A few of the markers — free to read

These explainers are free: what each one measures, the optimal range rather than just the lab range, and what actually moves it.

APOE Genotyping pTau-217 (AD-Detect)Vitamin B12 Methylmalonic Acid (MMA)

Frequently asked questions

What blood tests are in the Cognitive Decline & Alzheimer's Risk panel?

9 markers: pTau-217 (AD-Detect), APOE Genotyping, Vitamin B12, Methylmalonic Acid (MMA), Homocysteine, TSH (Thyroid-Stimulating Hormone), Vitamin D (25-Hydroxy), HbA1c (Hemoglobin A1c), hs-CRP (C-Reactive Protein, High Sensitivity).

How much does the Cognitive Decline & Alzheimer's Risk panel cost?

$675.95 before discount, $608.36 with code CAMERON applied automatically. Individual markers add a one-time $10 draw fee. Ordered through Marek Diagnostics and drawn at any Quest Diagnostics location in the US.

Do I need a doctor's order for these tests?

No. These are ordered direct-to-consumer through Marek Diagnostics — you order online, walk into a Quest location, and results are emailed to you in about two weeks. No physician visit or insurance required. Not available in NY, NJ or RI.

When should I get the Cognitive Decline & Alzheimer's Risk panel drawn?

Fast 9–12 hours, morning. Off B12 supplements 1 week if you want a true B12 reading.

Important: This page is education only, not medical advice and not a diagnosis. A panel is a starting point for a conversation with a clinician, not a substitute for one. Reference ranges vary by laboratory and assay — always compare against the range printed on your own report.