Syn-Ake (Raw)
Syn-Ake (Raw) is sold as a raw cosmetic material — you formulate it into a serum or cream yourself rather than buying it finished. What follows is what the molecule does, whether it survives the trip through skin, and how to handle it.
Syn-Ake (Raw) at a glance
| Sold by | Ion Peptide |
| Where it goes | Raw material — you formulate it |
| INCI name | Dipeptide Diaminobutyroyl Benzylamide Diacetate |
| Key active | SYN-AKE |
Does SYN-AKE actually work on skin?
This is a different question from whether it works injected, and the answer is often different too — a molecule has to survive the stratum corneum before any of its biology matters. Full SYN-AKE breakdown →
Human clinical evidence
- Supplier data only, reporting reduced expression lines. No independent replication of consequence.
Correlative data
- Marketed on its origin story — a synthetic analog of a peptide from temple viper venom. The story does more work than the data.
How the mechanism reads
- A dipeptide that antagonizes the nicotinic acetylcholine receptor post-synaptically, where Argireline and SNAP-8 act pre-synaptically — a different route to the same muscle-relaxation premise.
- And the same ceiling: the target sits below skin that the molecule has to cross first.
- A synthetic mimetic of waglerin-1, a peptide from temple viper venom, proposed to antagonize the nicotinic acetylcholine receptor at the muscle end plate. Different receptor from Argireline's SNARE interference, same downstream idea: less contraction, softer dynamic lines.
- The novelty is genuine and the evidence is the thinnest in this section — supplier data, small panels, no independent replication. It earns a place in a routine as an experiment, not as the active you build the routine around.
How to use Syn-Ake (Raw)
This is a raw active, not a finished product: you are buying the ingredient to formulate with. It needs a vehicle, a sensible concentration and a pH that suits the molecule before it does anything at all. Sits in the same expression-line category, and it is the thinnest evidence in the section — treat it as the experiment in your routine rather than the backbone of it.
Where to get Syn-Ake (Raw)
Buy Syn-Ake (Raw) at Ion Peptide →What bloodwork can and cannot tell you here
This acts at the neuromuscular junction in the skin you apply it to. It is not injected, it is not systemic, and there is no blood marker that reports on it.
What blood work covers is the other half of a line: dynamic creasing sets into a dermis, and how deeply it sets depends on the dermal thickness underneath — which is glycation, inflammation and substrate, and which is measurable.
| Marker | Why it matters for this |
|---|---|
| HbA1c (Hemoglobin A1c) | Glycation cross-links dermal collagen from the inside; no cream reaches that |
| hs-CRP (High-Sensitivity C-Reactive Protein) | Chronic inflammation degrades matrix faster than a serum rebuilds it |
| Ferritin | Under the skin-and-hair threshold, repair slows whatever you apply |
| Vitamin D (25-Hydroxy) | Commonly low, and barrier function and repair both depend on it |
| IGF-1 (Insulin-like Growth Factor 1) | The growth-longevity trade-off, and a direct driver of sebum output |
The Longevity Baseline panel covers these in one order — 13 markers, $219.10 with the discount applied.
Expression lines & topical neuromodulation → — the internal side of the same problem, and what to do about it.
Check results you already have → · All 103 markers A–Z
Other SYN-AKE products in the Vault
The rest of the routine
Every cosmetic in the Vault is free to read — mechanism, evidence, layering and where to buy, no login. What Skool adds is the compound side: 278 peptides and small molecules with dosing, cycling and the protocols that use them.
Join Skool — $10/mo →