Syn-Ake (Raw)
Syn-Ake (Raw) is sold as a raw cosmetic material — you formulate it into a serum or cream yourself rather than buying it finished. What follows is what the molecule does, whether it survives the trip through skin, and how to handle it.
Syn-Ake (Raw) at a glance
| Sold by | Ion Peptide |
| Where it goes | Raw material — you formulate it |
| INCI name | Dipeptide Diaminobutyroyl Benzylamide Diacetate |
| Key active | SYN-AKE |
| Availability | Out of stock at last check |
Does SYN-AKE actually work on skin?
This is a different question from whether it works injected, and the answer is often different too — a molecule has to survive the stratum corneum before any of its biology matters. Full SYN-AKE breakdown →
Human clinical evidence
- Supplier data only, reporting reduced expression lines. No independent replication of consequence.
Correlative data
- Marketed on its origin story — a synthetic analogue of a peptide from temple viper venom. The story does more work than the data.
How the mechanism reads
- A dipeptide that antagonises the nicotinic acetylcholine receptor post-synaptically, where Argireline and SNAP-8 act pre-synaptically — a different route to the same muscle-relaxation premise.
- And the same ceiling: the target sits below skin that the molecule has to cross first.
- A synthetic mimetic of waglerin-1, a peptide from temple viper venom, proposed to antagonise the nicotinic acetylcholine receptor at the muscle end plate. Different receptor from Argireline's SNARE interference, same downstream idea: less contraction, softer dynamic lines.
- The novelty is genuine and the evidence is the thinnest in this section — supplier data, small panels, no independent replication. It earns a place in a routine as an experiment, not as the active you build the routine around.
How to use Syn-Ake (Raw)
This is a raw active, not a finished product: you are buying the ingredient to formulate with. It needs a vehicle, a sensible concentration and a pH that suits the molecule before it does anything at all. Sits in the same expression-line category, and it is the thinnest evidence in the section — treat it as the experiment in your routine rather than the backbone of it.
Where to get Syn-Ake (Raw)
Buy Syn-Ake (Raw) at Ion Peptide →Other SYN-AKE products in the Vault
The rest of the routine
Every cosmetic in the Vault is free to read — mechanism, evidence, layering and where to buy, no login. What the Academy adds is the compound side: 237 peptides and small molecules with dosing, cycling and the protocols that use them.
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