ProExosome
ProExosome from Disguised Alpha, built on Exosomes. Below: what's in it, whether the active actually reaches the layer it needs to, where it goes in a routine, and what to expect.
ProExosome at a glance
| Sold by | Disguised Alpha |
| Where it goes | Serum — thinnest first |
| Key active | Exosomes |
Does Exosomes actually work on skin?
This is a different question from whether it works injected, and the answer is often different too — a molecule has to survive the stratum corneum before any of its biology matters. Full Exosomes breakdown →
Human clinical evidence
- No standardised controlled human evidence for topical cosmetic use. Regulators including the FDA have warned about unapproved *injectable* exosome products after adverse events — a statement about oversight, not about benefit.
Correlative data
- Common in clinics straight after microneedling or laser, with practitioner reports of faster settling. Note the confound: that is exactly when the barrier is open and when recovery is watched closely anyway.
- Independent testing of commercial products has repeatedly found particle counts and vesicle integrity far below label claims.
How the mechanism reads
- 30–150 nm vesicles carrying miRNA, mRNA and proteins between cells. Real biology, seriously studied.
- Three unsolved problems sit between that and a bottle: no standard (the word names a claimed source, not a dose or a cargo), fragility (processing and storage degrade them), and penetration of an intact vesicle through healthy skin is not established.
- Unproven is not ineffective — but nobody can tell you what a given bottle contains, and that uncertainty is the product you are buying. Price it in.
- The category has a labelling problem more than a science problem. True exosomes are nanovesicles carrying signalling cargo; a large share of products labelled 'exosome' are lysates or conditioned media — the contents of broken cells, not intact vesicles — and the two behave differently.
- Source and processing decide what is in them, and neither is usually disclosed. The honest position is that the mechanism is real and the products are unstandardised, which makes any individual result hard to attribute and impossible to reproduce across brands.
How to use ProExosome
Step 3 — Serum — thinnest first
**Post-procedure only is the honest recommendation.** On intact skin, vesicle penetration is not established. Best used on freshly cleansed or just-microneedled skin, where the barrier is most permeable. Nothing occlusive underneath it.
What to expect, and when
Unknown — read the Exosomes card first.
What not to layer with ProExosome
- Exosomes + Intact skin — The only setting with a real rationale is immediately post-procedure. On unbroken skin, penetration of an intact vesicle is not established.
Where to get ProExosome
Buy ProExosome at Disguised Alpha →Other Exosomes products in the Vault
The rest of the routine
Every cosmetic in the Vault is free to read — mechanism, evidence, layering and where to buy, no login. What the Academy adds is the compound side: 237 peptides and small molecules with dosing, cycling and the protocols that use them.
Join the Academy — $10/mo →