Metabolic calculator

HOMA-IR — Insulin Resistance

The standard research index of insulin resistance. Catches metabolic dysfunction years before glucose or HbA1c move.

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How this is worked out. HOMA-IR = (fasting glucose mg/dL × fasting insulin µIU/mL) / 405. Matthews et al., Diabetologia 1985. The 405 is the constant for glucose in mg/dL; the mmol/L form divides by 22.5.
Optimal is under 1.5. Above 2.5 indicates meaningful insulin resistance. Requires a fasted draw.

The bands on this page

ResultWhat it is called here
under 1.0Excellent — highly insulin sensitive
1.0 to 1.5Good
1.5 to 2.5Early insulin resistance — act now
over 2.5Significant insulin resistance

What goes in, and where each number comes from

Every input is a real test. Follow one to see its normal range, its optimal range and what moves it — the calculation is only as good as the numbers you feed it.

What it costs to actually get these numbers

The 2 tests on their own$17.10
The cheapest panel that covers them — Metabolic Health & Prediabetes (8 markers)$81.45
Order the tests, not the panel. This calculation needs 2 results, and buying them individually is $64.35 cheaper than the smallest panel that happens to contain them. The panel is worth it only if you want the other 6 markers on it too.
Order Metabolic Health & Prediabetes →

Prices are Marek Diagnostics with the 10% code already applied, and they are what was filed when this page was built — check the cart. Ordering through these links pays a commission at no cost to you.

What could have moved the measurement, not the marker

A wrong number and a real change look identical on a report. These are the reasons a result here can be an artifact of how the blood was drawn or run, and they are worth ruling out before anything else.

assayHemolysis (burst red cells)

Red cells rupturing in the tube spill their contents into the serum. Potassium, LDH, AST and magnesium are far higher inside cells than outside, so a hemolyzed sample reports them falsely high. Caused by a difficult draw, a narrow needle, or shaking the tube.

What to do: The lab usually flags it. If your result is odd and the report mentions hemolysis, that is your answer — repeat the draw.

prepFist clenching and tourniquet time

Clenching your fist pumps potassium out of muscle and can raise a measured potassium enough to trigger a false alarm. A long tourniquet concentrates protein, calcium and everything protein-bound.

What to do: Do not pump your fist. Ask for the tourniquet to come off early. An isolated high potassium with no symptoms is usually this.

timingFasting state

Rises after eating, so a non-fasted draw measures your breakfast rather than your baseline.

What to do: Draw fasted, 10–12 hours, water only.

timingRecent carbohydrate

Insulin responds within minutes to eating. Even a coffee with milk the morning of the draw will move it, and it is far more sensitive to this than glucose.

What to do: 12 hours fasted, water only. This marker is unusually unforgiving.

3 more interferences are listed on the marker pages themselves: Comprehensive Metabolic Panel (CMP) · Fasting Insulin.

This tool does not diagnose anything. It puts a number next to a published interval and shows the arithmetic that got there. It cannot see your symptoms, your medications, your history or the assay your lab ran. A result outside the outer bounds belongs in front of a clinician, not in a supplement search.

Where to go with this

Read one of these results on its ownType a value, pick your units and sex, and see where it sits and what could have moved it.The Metabolic Health & Prediabetes8 markers, $81.45 with the code — what it settles and what it does not.Every marker on this site103 markers, each with the normal range, the optimal range and what moves it.

The other metabolic calculations

QUICKI — Insulin SensitivityA companion to HOMA-IR that some researchers consider more reliable at the low-insulin end. Higher is better here.TyG Index — Insulin Resistance (no insulin needed)Estimates insulin resistance from just triglycerides and glucose — useful when you didn't order fasting insulin.Estimated Average Glucose (from HbA1c)Converts your HbA1c into the average blood glucose it represents — far more intuitive than a percentage.