The Bioregulator Blueprint
Two courses a year, five arms, one pick each
Everything on this page is free. The stack, why each pick beat its alternatives, every option, the bloodwork and the safety lines. The week-by-week schedule and the decision rules are the members half.
Khavinson peptides are very short amino acid sequences — often just two to four — each associated with one tissue. The proposed mechanism is that they act as signalling molecules telling a specific tissue to normalise its own gene expression, rather than supplying anything the tissue is short of. That is a genuinely different idea from every other page on this site, and it is why the dosing convention is so unusual: microgram-to-milligram amounts, ten days on, then months off. You are sending a signal, not maintaining a level. Pick by the tissue you actually want to work on. Running six at once is the commonest mistake and it makes the result impossible to read.
Can you run all of them? Not this time - and here is why
This is a general protocol. You make the final call on how much of it to run — or have it built around your labs.
Which of these 5 is actually you?
This tells you where your biggest leverage is — where to start, not where to stop. Read the But line too: it is what each lane cannot do for you, which is the part a list of options never tells you.
Before any of it — the foundation
These four are not a disclaimer at the bottom of the page. They are the reason the rest of it works, and every one of them is free.
Growth hormone is released in pulses during deep sleep, insulin sensitivity is measurably worse after one bad night, and appetite regulation collapses without it. Every compound below works through a system that sleep already governs. This is not filler advice — it is the highest-leverage item on the page and it is free.
The single dietary variable with the most consistent evidence behind it for body composition, in both directions — building and preserving. Under-eating protein while running anything anabolic is paying for a signal with no substrate to act on.
Nothing here substitutes for mechanical tension. Compounds change how well you recover from and adapt to training; they do not replace the stimulus. A protocol run without training reliably produces the side effects and not the results.
Non-exercise activity is the largest and most variable component of daily energy expenditure, and it is the one that quietly falls when you start dieting. Tracking it stops the metabolic adaptation people blame on their thyroid.
The stack
This needs saying more directly here than anywhere else on the site. The evidence base for this entire category is almost exclusively one research group's, mostly published in Russian, and rarely replicated independently. That is not a reason to dismiss it — Khavinson's group has decades of work and some of it is long-duration — but it is a reason to treat any course as an experiment you measure rather than a protocol you trust. Unproven is not the same as ineffective. It is also not the same as proven, and this is the page where that distinction does the most work.
Each pick names what it was chosen over and why. That is the difference between a blueprint and a list — if you disagree with a choice, the alternative is right there and swapping it does not break the rest.
Peptides 3
Short amino-acid chains that signal rather than force. Almost all are injected or intranasal, they need reconstituting, and they are the reason most people are on this site.
The pineal peptide complex, and the centrepiece of most Khavinson longevity protocols — it sits at the top of the endocrine cascade rather than at one gland. Frequently run as the base course with a tissue-specific peptide alongside it.
Testoluten and Testagen target testicular tissue — note they act on the TISSUE, not the hormonal axis above it, so they are not alternatives to enclomiphene or hCG. Ovagen is the female counterpart. Prostamax targets prostate. Suprefort targets pancreas. Endoluten is the base because it is the upstream one — and because it overlaps heavily with Epitalon, which is worth knowing before buying both.
Stack this arm deeper5 optional add-ons
Each of these sits in this same pathway, so it starts the week this pathway starts. Swapping one in for the pick above does not change the schedule.
Testicular tissue specifically. The distinction that matters: this acts on the tissue, not on the pituitary signal above it — so it is complementary to the testosterone blueprint's arms rather than a substitute for them.
The trade-off If your LH is low, the problem is upstream and this arm is not aimed at it.
Prostate tissue — the reason many men over fifty look at this category at all.
The trade-off Baseline PSA before starting. Without it, a later reading has nothing to be compared against.
Pancreatic tissue, both the digestive and the insulin-producing side — which makes it one of the few here with an obvious number attached.
The trade-off Measure fasting insulin and HbA1c or you will have no idea whether it did anything.
The testicular bioregulator — the male half of this arm, where Ovagen is the female one.
The trade-off Same evidence caveat as the whole category. Enclomiphene and hCG have actual trials for the same endpoint.
The pancreatic bioregulator, aimed at insulin-producing tissue — the one in this arm with a checkable endpoint, because fasting insulin and HbA1c are cheap to draw.
The trade-off Metformin, berberine and the incretins all have real trials for the same target.
Vascular, cardiac & structuralChelohart5 options
5 options — 0 to swap in, 5 to stack ontap to collapse
Liver, kidney, gut & lungSvetinorm5 options
5 options — 0 to swap in, 5 to stack ontap to collapse
Bioregulators 2
Khavinson peptides - two to four amino acids, each associated with one tissue, dosed as short courses months apart rather than continuously. The most speculative class here, and the page says so.
Thymus & immuneThymalin4 options
4 options — 0 to swap in, 4 to stack ontap to collapse
Brain & pinealEpitalon4 options
4 options — 0 to swap in, 4 to stack ontap to collapse
Health supplements & substrate
The floor underneath the compounds. Cheap, well tolerated, and the part that decides whether anything above it has a fair chance — a secretagogue on a magnesium deficiency is a rounding error.
The 12-week schedule
What goes in, what comes out, and when. The exact doses for each phase are inside the Academy — the structure below is free because it is the part you need to decide whether this fits your life.
Each bar is a week block that compound is running. The shape is free — it is what tells you whether this fits your life. The doses for each phase are the members half.
Ten days. Measure before and after.
Bloodwork before the course, not after it starts. This is a category where the effect is subtle enough that without a baseline you will simply believe whatever you expected to believe.
Repeat, and use the same measures.
Same peptides if the first course moved something. Different tissue if it did not and you want to keep exploring — but be honest that 'nothing measurable happened' is a legitimate result to act on.
Twice yearly at most, and only if it earned it.
This is the category where the enthusiasm most outruns the evidence, and nobody else will tell you to stop. Two properly measured courses with no movement in any marker and nothing you can feel is a real answer, and the money is better spent on the cardiovascular or metabolic pages.
Twice yearly at most, and only if it earns it.
If two courses produced no change in any marker and nothing you can feel, stop. This is the category where that discipline matters most, because the enthusiasm outruns the evidence and nobody else will tell you.
The doses for each phase are inside
Every compound above, dosed week by week, plus the reconstitution numbers and Coach Cam's notes on running it. $10/mo.
Unlock the schedule →Bloodwork
Bloodwork is not optional on this page — it is the only thing separating an experiment from a belief. Nothing here produces a reliable feeling, and this is the category most prone to expectation doing the work. Match the panel to the arm. Immune → CBC with differential, particularly lymphocytes. Liver → ALT, AST and GGT on the CMP. Kidney → eGFR and creatinine, with cystatin C if you are muscular. Prostate → baseline PSA before anything. Cardiac and vascular → ApoB and hs-CRP. Draw before the course and again 4–6 weeks after it ends. If nothing moved across two courses, that is a real answer.
Before you start
Everything, drawn before you start. This is the one that decides which pathway is actually yours - and the only one you cannot go back and collect later.
Around week 8
The short list, drawn while you are running it. Not a progress report - it is the draw that catches the things that go wrong quietly.
After
Drawn at the end, against your own baseline. This is what turns the protocol into information rather than a feeling.
All three are drawn at Quest, 2,000+ US locations, no doctor visit, HSA/FSA eligible. Prefer to pick and choose? Every marker above links to its own page, and the panel builder assembles any combination.
Adjusting it
A protocol you cannot adjust is a protocol you abandon. Four situations come up on nearly every run of this — nausea that will not settle, a three-week stall, hair shedding, glucose moving the wrong way. Each one has a specific answer, and the wrong answer to a stall is the reason most people end up on six compounds that each do nothing.
The four decision rules are inside
What to change, what to leave alone, and how to tell a real stall from a water shift. $10/mo.
Unlock the decision rules →The lines I'd stop at
- Any injection-site reaction that is spreading, hot, or worsening after 48 hours. That is infection rather than irritation.
- A new lump, or a mole that changes. Nothing here is established as causing that — and nothing in this category is worth running while an unexplained finding is unexplained.
- Any new symptom that started with a course and has not settled a month after it ended. The whole model says the effect should be transient; something persisting is worth taking seriously.
- Any injection-site reaction that is spreading, hot, or worsening after 48 hours.
- A new lump, or a mole that changes. Nothing here is established as causing that, and no speculative category is worth running while an unexplained finding is unexplained.
It is built for the common case, not for you specifically. Compound selection and dosing genuinely do change person to person — training age, bloodwork, what you have run before, what you react to. Adjust it against your own numbers using the panels above, or if you want it built around your labs rather than the average, that is what 1-on-1 coaching is for.