Sirolimus (Rapamycin), Whole Blood
Therapeutic drug monitoring for sirolimus/rapamycin — an mTOR inhibitor used clinically in transplant medicine, and increasingly discussed in longevity circles.
Included because rapamycin has become a prominent longevity topic. Level monitoring matters because the therapeutic window is narrow and side effects are dose-dependent — and because this is genuinely investigational territory for longevity use.
Optimal ranges, root causes, and the complete correction protocol — nutrition, supplements, lifestyle, hormones and peptides — plus 100+ other markers.
Unlock everything — $10/mo →📚 Transplant therapeutic drug monitoring guidance. Mannick JB et al., Sci Transl Med 2014 — mTOR inhibition and immune function in older adults.
🩸 Test your Sirolimus (Rapamycin), Whole Blood
Order directly through Marek Diagnostics — no doctor's visit needed, drawn at any Quest location in the US. Code CAMERON applies 10% off automatically.
Order this test — 10% off → Browse all 102 markers →What Sirolimus (Rapamycin), Whole Blood is usually tested alongside
On its own, one marker is a data point. These panels include Sirolimus (Rapamycin), Whole Blood plus the markers that make it interpretable — each names every test, why it is on the list, and loads the whole set into your cart in one click at 10% off.
includes this + 12 more markers — Healthy, asymptomatic, and want the most informative baseline you can get — the panel to run once a year and track for decades.
includes this + 6 more markers · built for men — Never had proper bloodwork, or want the highest-value snapshot for the least money.
includes this + 6 more markers · built for women — Never had proper bloodwork, or want the highest-value snapshot for the least money.
What moves your Sirolimus (Rapamycin), Whole Blood
1 compound in the Vault have a documented effect on this marker, or are a reason to have measured it first:
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Why your Sirolimus (Rapamycin), Whole Blood might be wrong
Most abnormal results are interference, not disease. These are the things that measurably move this specific marker — check them before you change anything. Each one says whether the number is wrong and should be repeated, badly timed and should be redrawn, or real with a cause worth explaining.
Reported against a trough range. Timing relative to the dose is the single largest determinant of the number.
Draw immediately before the next dose.
Grapefruit, clarithromycin, azole antifungals and many others raise levels substantially; rifampicin and St John's Wort lower them.
This is a narrow-window drug — any new medication or supplement needs prescriber review.
What Sirolimus (Rapamycin), Whole Blood means in combination
A single marker tells you a little. Combinations tell you the story — these are the named patterns this marker takes part in, and what each one points at.
Both are narrow-therapeutic-window drugs reported against a trough range, and timing relative to the dose is the single largest determinant of the number. A lithium drawn four hours after the dose is far higher than the same person's true trough.
Lithium: exactly 12 hours after the evening dose. Sirolimus: immediately before the next dose. New medications matter enormously — NSAIDs and diuretics raise lithium, CYP3A4 inhibitors raise sirolimus. Tremor, vomiting or confusion on lithium is toxicity and an emergency.
What to test next
Markers rarely answer alone. These are the ones that put Sirolimus (Rapamycin), Whole Blood in context — each with its own full breakdown.
Frequently asked questions
Transplant therapeutic ranges 4–20 ng/mL depending on protocol; longevity protocols use intermittent, much lower exposure Ranges vary by laboratory and assay — always compare to the range printed on your own report.
Optimal ranges, root causes and the full correction protocol are available inside Coach Cam's Peptide Academy.
See the full breakdown inside the Academy.
See the full breakdown inside the Academy.
You can order Sirolimus (Rapamycin), Whole Blood directly through Marek Diagnostics without a doctor's visit — drawn at any Quest Diagnostics location in the US. Code CAMERON applies 10% off automatically.