Bone & fracture healing
One of 5 mechanistic pathways to 🩹 Heal an injury · 11 options
Bone is the one connective tissue that can genuinely regenerate rather than scar — and the only one where anabolic drugs reliably build new tissue. The key distinction is anabolic (build) versus anti-resorptive (stop losing), and they are not interchangeable.
Vitamin D and PTH together tell you whether calcium is being absorbed or pulled out of your skeleton to keep blood levels normal. A normal blood calcium with a high PTH is bone loss in progress — and it reads as 'fine' on a standard panel.
Vitamin D (25-Hydroxy)Parathyroid Hormone & CalciumOsteocalcinComprehensive Metabolic Panel (CMP)Total Testosterone🦴 Bone Density & Fracture Risk covers these in one panel →
What engages this pathway
Ordered by how directly each one acts on the mechanism above — never by how much trial evidence exists. Each links to its full breakdown with dosing, half-life and vendor.
💉 Teriparatide
Intermittent PTH is anabolic to bone — continuous PTH is catabolic, and the pulsatility is the entire mechanism. Approved for osteoporosis, and used off-label for stubborn non-union fractures with real case-series support.
💉 Abaloparatide
A PTHrP analog with greater selectivity for the anabolic receptor conformation. Faster bone-density gain than teriparatide with less hypercalcaemia.
💉 Cartalax
A cartilage bioregulator peptide from the Khavinson series. The peptide-bioregulator literature is almost entirely Russian and rarely independently replicated — treat the whole class as mechanistically interesting and evidentially thin.
💉 Sigumir
Cartilage and bone bioregulator from the same series. Same caveat, same interest.
🧬 Vitamin D
Required for calcium absorption. Deficiency directly impairs fracture healing, and it is the single most common correctable deficiency in a delayed union.
🧬 Vitamin K2 Complex
Carboxylates osteocalcin, which is what directs calcium into bone rather than into arteries. The mechanism that makes vitamin D safe at higher doses.
🧬 Calcium & Magnesium
The mineral substrate itself. Necessary, insufficient alone, and pointless without D and K2 to direct it.
🧬 Strontium
Substitutes for calcium in the hydroxyapatite lattice and appears to both stimulate formation and inhibit resorption. Note it inflates DEXA readings because it's denser than calcium — the scan overstates the gain.
🧬 Boron
Influences calcium, magnesium and vitamin D metabolism, and reduces urinary calcium loss in small studies.
🧬 Silica
Involved in the early stages of bone matrix mineralisation in animal work.
🧬 Collagen
Bone is roughly a third collagen by weight — the protein scaffold the mineral is deposited onto. Trials show improved bone density with peptide supplementation in postmenopausal women.
The other 4 routes to heal an injury
Pick the pathway that matches where you are actually stuck. An appetite drug does nothing for someone who already undereats.
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Frequently asked questions
Bone is the one connective tissue that can genuinely regenerate rather than scar — and the only one where anabolic drugs reliably build new tissue. The key distinction is anabolic (build) versus anti-resorptive (stop losing), and they are not interchangeable.
11 options are mapped to this pathway in the Vault, including Teriparatide, Abaloparatide, Cartalax, Sigumir. They are grouped by the mechanism they act through rather than ranked by how much trial evidence exists — 7 carry clinical validation and 4 are mechanistic predictions.
Vitamin D and PTH together tell you whether calcium is being absorbed or pulled out of your skeleton to keep blood levels normal. A normal blood calcium with a high PTH is bone loss in progress — and it reads as 'fine' on a standard panel. The markers worth checking are Vitamin D (25-Hydroxy), Parathyroid Hormone & Calcium, Osteocalcin, Comprehensive Metabolic Panel (CMP).
Unproven is not the same as ineffective. Of the 11 options on this pathway, 7 have clinical validation and 4 are graded theoretical — meaning the mechanism is sound but the specific human trial has not been run, which is true of a great deal of what works in this space. Nothing on this page is ordered by evidence tier, because sorting by trial count would bury the compounds you came looking for.